文献発表 Publication
2025
Yasuhiko Izumi*, Norihiko Takeda, Shuzo Nishimoto, Honoka Niimi, Sayuri Ishizu, Natsumi Muneyasu,
Yuto Takamatsu, Emi Mishiro-Sato, Keiko Kano, Kouya Yamaki, Takahiro Yamada, Yutaka Koyama,
Masafumi Ueda
“Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures”,
Bioorg. Med. Chem., 2026, 132, 118454.
(https://www.sciencedirect.com/science/article/pii/S0968089625003955?via%3Dihub#s0145)
本学薬理学研究室との共同研究の成果です！当研究室で合成したKU-0479は老化に効くかも？
Yasuhiko Izumi*, Eri Koide, Fumika Kobayashi, Saori Ikawa, Midai Takayama, Kouya Yamaki, Norihiko Takeda, Takahiro Yamada, Masafumi Ueda, Toshiaki Kume, Yutaka Koyama,
“TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathways”,
J. Pharmacol. Sci., 2025, 159, 35-43. (https://doi.org/10.1016/j.jphs.2025.07.001)
Norihiko Takeda, Sora Fujita, Kaho Murakami, Chihiro Honda, Hina Tomoda, Motohiro Yasui, Takahiro Yamada, Masafumi Ueda*,
“Zinc(II)-catalysed cyclocondensation of oxime ethers triggered by polarity inversion: construction of fused pyrroles”,
Chem. Commun., 2025, 61, 7995-7998. (DOI: 10.1039/D5CC01362C)
(プレスリリース)
本論文のイメージ図がOutside front cover (表紙)に選ばれました。
